Colorectal Large Cell Neuroendocrine Carcinoma

**Semantic type:** Neoplastic Process

**Definition:** An aggressive high-grade carcinoma with neuroendocrine differentiation that arises from the colon or rectum and is composed of malignant large cells. The mitotic count is more than 20 per 2 mm2 and/or the Ki-67 index is more than 20%.