Topical Piperidine Nitroxide MTS-01

**Semantic type:** Pharmacologic Substance

**Definition:** A topical gel containing a cell permeable hydrophilic piperidine nitroxide with potential radioprotective and antioxidant activity. As a stable, free radical compound, MTS-01 may be able to protect cells against the damaging effects of reactive oxygen species (ROS), upon exposure to ionizing radiation and oxidative stress. The topically applied MTS-01 may protect normal tissue from radiation-induced toxicity, such as radiation dermatitis, during radiation therapy.

**Synonyms:** - 1-Piperidinyloxy, 4-Hydroxy-2,2,6,6-tetramethyl- - 4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl - MTS-01 - TEMPOL - Tempol