Anal Canal Large Cell Neuroendocrine Carcinoma

**Semantic type:** Neoplastic Process

**Definition:** An aggressive high-grade carcinoma with neuroendocrine differentiation that arises from the anal canal and is composed of malignant large cells. The mitotic count is more than 20 per 2 mm2 and/or the Ki-67 index is more than 20%.

**Synonyms:** - Anal Canal Large Cell NEC - Anal Large Cell NEC - Anal Large Cell Neuroendocrine Carcinoma