Ceftaroline Fosamil Acetate

**Semantic type:** Antibiotic|Pharmacologic Substance

**Definition:** The acetic acid salt form of ceftaroline fosamil, an N-phosphono type prodrug of the fifth-generation cephalosporin derivative ceftaroline with antibacterial activity. Ceftaroline fosamil, when hydrolyzed to the active form ceftaroline, has a high affinity for penicillin binding protein 2a (PBP2a), which is associated with methicillin resistance. As a result, ceftaroline is unique in its activity against methicillin-resistant, vancomycin-intermediate, linezolid-resistant, and daptomycin-nonsusceptible strains.

**Synonyms:** - (6R,7R)-7-(((2Z)-(Ethoxyimino)(5-(phosphonoamino)-1,2,4-thiadiazol-3-yl)acetyl)amino)-3-((4-(1-methylpyridinium-4-yl)thiazol-2-yl)sulfanyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-2-carboxylate Monoacetate - CEFTAROLINE FOSAMIL ACETATE - Ceftaroline Fosamil Monoacetate - Ceftaroline Fosamil Monoacetate Monohydrate - PPI-0903 Monoacetate Monohydrate - TAK-599 Monoacetate Monohydrate