Rosiglitazone Cholinate

**Semantic type:** Pharmacologic Substance

**Definition:** The cholinate salt form of rosiglitazone, an agent belonging to the glitazone class of antidiabetic agents with antihyperglycemic and anti-inflammatory activities. In addition to its ability to lower blood glucose levels, rosiglitazone also exerts anti-inflammatory activity through its ability to inhibit nuclear factor-kappaB (NF-KB) activity and increase I-kappaB levels. In addition, rosiglitazone may cause fluid retention and may worsen congestive heart failure. This agent is also associated with an increased risk of heart attacks.

**Synonyms:** - Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, ((4-(2-(methyl-2-pyridinylamino)ethoxy)phenyl)methyl)-2,4-thiazolidinedionate (1:1) - ROSIGLITAZONE CHOLINATE