5-Fluorouracil/Salicylic Acid Topical Solution

**Semantic type:** Pharmacologic Substance

**Definition:** A topical formulation containing 0.5 % of antimetabolite 5-fluorouracil (5-FU) and 10% of salicylic acid, with potential antimitotic and keratolytic activity. Upon cutaneous application, 5-FU in the 5-fluorouracil/salicylic acid topical solution impedes pyrimidine metabolism thereby inhibiting cell growth, while the salicylic acid induces anti-inflammatory response and results in keratolytic effect. This may result in the breakdown of keratinocytes and prevent proliferation of keratinocytes locally.

**Synonyms:** - Actikerall - LAS 41005 - Low-dose 5-Fluorouracil/Salicylic Acid