TP53*1 Allele

**Semantic type:** Gene or Genome

**Definition:** Human TP53*1 allele is located in the vicinity of 17p13.1 and is approximately 19 kb in length. This allele, which encodes cellular tumor antigen p53*1 protein, is involved in apoptosis and tumor suppression. This variant exhibits a coding change from a proline at amino acid 72 to an arginine, which may affect the activity and stability of the encoded protein.

**Synonyms:** - TP53 Codon 72 Polymorphism - TP53 P72R - TP53 c.215C>G - TP53 p.Pro72Arg - Tumor Protein p53*1 Allele