ATIC wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human ATIC wild-type allele is located in the vicinity of 2q35 and is approximately 38 kb in length. This allele, which encodes bifunctional purine biosynthesis protein PURH, is involved in the synthesis of purines. A chromosomal inversion inv(2)(p23q35) involving this gene and the ALK gene is associated with rare cases of ALK-positive anaplastic large cell lymphoma.

**Synonyms:** - 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase wt Allele - AICAR - AICAR Formyltransferase/IMP Cyclohydrolase Bifunctional Enzyme Gene - AICARFT - AICARFT/IMPCHASE - FLJ93545 - IMPCHASE - OK/SW-cl.86 - PURH - Phosphoribosylaminoimidazolecarboxamide Formyltransferase/IMP Cyclohydrolase Gene