CLTC wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human CLTC wild-type allele is located within 17q11-qter and is approximately 77 kb in length. This allele, which encodes clathrin heavy chain 1 protein, is involved in both receptor-mediated endocytosis and vesicle formation. A translocation t(2;17)(p23;q23) of this gene and the ALK gene is associated with anaplastic large cell lymphoma and inflammatory myofibroblastic tumors. Xp11 translocated renal carcinomas are associated with a translocation t(X;17)(p11;q23) of this gene and the TFE3 gene.

**Synonyms:** - CHC - CHC17 - CLH-17 - CLTCL2 - Clathrin Heavy Chain wt Allele - Clathrin, Heavy Chain (Hc) Gene - Clathrin, Heavy Chain Gene - Clathrin, Heavy Polypeptide (Hc) Gene - Clathrin, Heavy Polypeptide-Like 2 Gene - KIAA0034