CRLF2 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human CRLF2 wild-type allele is located in the vicinity of Xp22.3 and Yp11.3 and is approximately 17 kb in length. This allele, which encodes cytokine receptor-like factor 2 protein, plays a role in the modulation of cytokine signaling. A chromosomal deletion in the pseudoautosomal region 1 of either chromosome X or Y causing fusion of this gene with the P2RY8 gene and chromosomal translocations t(X;14)(p22;q32)/t(Y;14)(p11;q32) of this gene and the IGH locus are associated with B-cell acute lymphoblastic leukemia.

**Synonyms:** - CRL2 - CRLF2Y - Cytokine Receptor Crl2 Gene - Cytokine Receptor Like Factor 2 wt Allele - Cytokine Receptor-Like Factor 2 Gene - TSLPR - Thymic Stromal-Derived Lymphopoietin Receptor Gene