DUX4 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human DUX4 wild-type allele is located in the vicinity of 4q35.2 and is approximately 2 kb in length. This allele, which encodes double homeobox protein 4, is involved in the modulation of transcription. This gene is within a D4Z4 repeat array; contraction of this macrosatellite repeat is associated with facioscapulohumeral muscular dystrophy (FSHD). A chromosomal translocation t(4;19)(q35;q13) involving this gene and the CIC gene is associated with soft tissue sarcoma.

**Synonyms:** - DUX10 - DUX4L - Double Homeobox 10 Gene - Double Homeobox 4 Like Gene - Double Homeobox 4 wt Allele