GMPS wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human GMPS wild-type allele is located in the vicinity of 3q24 and is approximately 70 kb in length. This allele, which encodes GMP synthase [glutamine-hydrolyzing], is involved in the modulation of purine synthesis. A chromosomal translocation t(3,11)(q25,q23) of this gene and the MLL gene is associated with treatment-related acute myeloid leukemia.

**Synonyms:** - GMP Synthase Gene - Guanine Monphosphate Synthetase wt Allele - Guanosine 5'-Monophosphate Synthase Gene