4-Nitroestrone 3-Methyl Ether

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic derivative of estradiol. 4-nitroestrone 3-methyl ether inhibits estrogen sulfotransferase (EST), a progesterone-induced secretory endometrial enzyme which affects estrogen receptor levels. This agent has been shown to be an effective growth inhibitor of some chemically induced animal mammary tumors. (NCI04)

**Synonyms:** - 3-METHOXY-4-NITRO-ESTRA-1,3,5(10)-TRIEN-17-ONE - 3-Methoxy-4-nitro-estra-1,3,5(10)-trien-17-one - 4-Nitroestrone - 4-Nitroestrone 3-methyl ether