POU2AF1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human POU2AF1 wild-type allele is located in the vicinity of 11q23.1 and is approximately 103 kb in length. This allele, which encodes POU domain class 2-associating factor 1 protein, plays a role in both transcriptional modulation and the B-cell response to antigen exposure. A chromosomal translocation t(3;11)(q27;q23.1) of this gene and the BCL6 gene may be associated with both non-Hodgkin lymphoma and B-cell leukemia.

**Synonyms:** - BOB1 - OBF-1 - OBF1 - OCAB - POU Class 2 Associating Factor 1 wt Allele - POU Domain Class 2, Associating Factor 1 Gene