PRKAR1A wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human PRKAR1A wild-type allele is located within 17q23-q24 and is approximately 21 kb in length. This allele, which encodes cAMP-dependent protein kinase type I-alpha regulatory subunit protein, is involved in the modulation of protein kinase A activation. Mutation of the gene is associated with Carney complex type 1, intracardiac myxoma, and primary pigmented nodular adrenocortical disease type 1. Papillary thyroid carcinoma is associated with a chromosomal translocation of this gene and the RET gene. A chromosomal aberration affecting this gene and the RARA gene is associated with acute promyelocytic leukemia.

**Synonyms:** - ACRDYS1 - ADOHR - CAR - CNC - CNC1 - Carney Complex Type 1 Gene - DKFZp779L0468 - MGC17251 - PKR1 - PPNAD1 - PRKAR1 - Prkar1alpha - Protein Kinase A Type 1a Regulatory Subunit Gene - Protein Kinase A, RI-Alpha Subunt Gene - Protein Kinase cAMP-Dependent Type I Regulatory Subunit Alpha wt Allele - Protein Kinase, cAMP-Dependent, Regulatory Subunit Type I Alpha Gene - Protein Kinase, cAMP-Dependent, Regulatory, Type I, Alpha (Tissue Specific Extinguisher 1) Gene - Protein Kinase, cAMP-Dependent, Regulatory, Type I, Alpha Gene - TSE1 - Tissue Specific Extinguisher 1 Gene - cAMP-Dependent Protein Kinase Regulatory Subunit RIalpha Gene - cAMP-Dependent Protein Kinase Type I-Alpha Regulatory Chain Gene