SDHD wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human SDHD wild-type allele is located in the vicinity of 11q23 and is approximately 33 kb in length. This allele, which encodes succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial protein, is involved in the localization of enzyme activity of the electron transport chain. Mutation of the gene is associated with hereditary paraganglioma type 1, pheochromocytoma, Carney-Stratakis syndrome and Cowden-like syndrome. Mutations also may be associated with intestinal carcinoid tumor.

**Synonyms:** - CBT1 - CII-4 - CWS3 - PGL - PGL1 - QPs3 - SDH4 - Succinate Dehydrogenase 4, Integral Membrane Protein Gene - Succinate Dehydrogenase Complex Subunit D wt Allele - Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein Gene - cybS