SOCS1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human SOCS1 wild-type allele is located in the vicinity of 16p13.13 and is approximately 2 kb in length. This allele, which encodes suppressor of cytokine signaling 1 protein, plays a role in the negative regulation of cytokine signaling. Mutation of the gene is associated with Hodgkin lymphoma and primary mediastinal B-cell lymphoma. Aberrant methylation of the gene is associated with a large number of cancers and other diseases.

**Synonyms:** - CIS1 - CISH1 - Cytokine-Inducible SH2 Protein 1 Gene - JAB - SOCS-1 - SSI-1 - SSI1 - STAT Induced SH3 Protein 1 Gene - Suppressor of Cytokine Signaling 1 wt Allele - TIP3