SRGAP3 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human SRGAP3 wild-type allele is located in the vicinity of 3p25.3 and is approximately 382 kb in length. This allele, which encodes SLIT-ROBO Rho GTPase-activating protein 3, is involved in the modulation of signaling by small GTPases. A chromosomal translocation t(X;3)(p11.2;p25) affecting the gene is associated with one patient with severe idiopathic mental retardation. Recombination of chromosome 3 affecting this gene and the RAF1 gene may be associated with astrocytoma.

**Synonyms:** - ARHGAP14 - KIAA0411 - MEGAP - SLIT-ROBO Rho GTPase Activating Protein 2 Gene - SLIT-ROBO Rho GTPase Activating Protein 3 wt Allele - SRGAP2 - WRP