TPM3 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human TPM3 wild-type allele is located in the vicinity of 1q21.2 and is approximately 39 kb in length. This allele, which encodes tropomyosin alpha-3 chain protein, is involved in the mediation of muscle filament movement. Mutation of the gene is associated with nemaline myopathy type 1 and thyroid papillary carcinoma. A chromosomal rearrangement affecting this gene and the NTRK gene is associated with thyroid papillary carcinoma. A chromosomal translocation t(1;2)(q25;p23) of the gene and the ALK gene is associated with rare cases of both anaplastic large cell lymphoma and inflammatory myofibroblastic tumors.

**Synonyms:** - FLJ41118 - MGC14582 - MGC3261 - MGC72094 - NEM1 - OK/SW-cl.5 - RP11-205M9.1 - TM-5 - TM3 - TM30 - TM30nm - TM5 - TPMsk3 - TRK - Tropomyosin 3 wt Allele - hscp30