Namilumab

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A human IgG1, monoclonal antibody targeting GM-CSF, with immunomodulating activity. Namilumab binds to and neutralizes GM-CSF, by preventing GM-CSF from binding to its cell surface receptor, GM-CSFR. This leads to an inhibition of GM-CSF-mediated signaling and ultimately prevents inflammation. GM-CSF, a pro-inflammatory cytokine, stimulates the production of granulocytes and monocytes; it plays a key role in the activation of the innate immune system and in various autoimmune and inflammatory diseases.

**Synonyms:** - Immunoglobulin G1, Anti-(Human Colony-Stimulating Factor 2) (Human Monoclonal MT203 Heavy Chain), Disulfide With Human Monoclonal MT203 Kappa-Chain, Dimer - MT203 - NAMILUMAB