Etrolizumab

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A humanized monoclonal antibody targeting the beta7 subunit of the heterodimeric integrins alpha4beta7 and alphaEbeta7, with anti-inflammatory activity. Etrolizumab binds to the beta subunit of the alpha4beta7 and alphaEbeta7 integrins in the gastronintestinal tract blocking their activity. This prevents integrin-mediated leukocyte migration to and accumulation in sites of inflammation.

**Synonyms:** - Anti-Beta7 - ETROLIZUMAB - Immunoglobulin G1, anti-(human integrin alpha4beta7/integrin alphaEbeta7) (human-rat monoclonal rhuMAb beta7 heavy chain), disulfide with human-rat monoclonal rhuMAb beta7 light chain, Dimer - PRO145223 - RG7413 - rhuMAb Beta7