Immunocytokine PDS01ADC

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A recombinant fusion protein consisting of the heavy-chains of the human immunoglobulin G1 (IgG1) monoclonal antibody NHS76, raised against DNA released by necrotic tumor cells, and fused to two molecules of a genetically modified human interleukin-12 (IL-12) with potential immunostimulating and antineoplastic activities. Upon administration, the antibody moiety of immunocytokine PDS01ADC binds to DNA released from necrotic tumor cells located primarily at the core of necrotic solid tumors, thereby delivering the IL-12 moiety. In turn, the IL-12 moiety of this agent stimulates the host immune system to mount an immune response against tumor cells, thereby inhibiting tumor growth. IL-12 is a proinflammatory cytokine with numerous immunoregulatory functions and may augment host immune responses to tumor cells. By targeting tumor cells, PDS01ADC may reduce the toxicity associated with systemic administration of recombinant human IL-12.

**Synonyms:** - IMMUNOCYTOKINE NHS-IL12 - Immunocytokine NHS-IL12 - M-9241 - M9241 - NHS-IL-12 - NHS-IL12 - PDS01ADC - PDS01ADC