TLX3 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human TLX3 wild-type allele is located in the vicinity of 5q35.1 and is approximately 3 kb in length. This allele, which encodes T-cell leukemia homeobox protein 3, may play a role in the regulation of transcription. T-cell leukemia is associated with mutation or aberrant expression of the gene and with at least two chromosomal translocations that include the gene. Translocation t(5;14)(q35;q32) fuses this gene and the BCL11B gene and translocation t(5;14)(q35;q11) fuses this gene with the T cell receptor delta locus.

**Synonyms:** - HOX11L2 - Homeo Box 11-Like 2 Gene - MGC29804 - RNX - T Cell Leukemia Homeobox 3 wt Allele - T-Cell Leukemia Homeobox 3 Gene - T-Cell Leukemia, Homeobox 3 Gene