Niacin-based Antilipidemic Agent

**Semantic type:** Chemical Viewed Functionally

**Definition:** An antilipidemic agent that works through, or mimics, the action of niacin to increase HDL-C levels by blocking hepatic uptake of apolipoprotein A-1 and decreasing HDL clearance. The use of free niacin is limited by its side effects of skin flushing (i.e., redness, itching, burning, and paresthesias).