PML/RARA Fusion Gene

**Semantic type:** Gene or Genome

**Definition:** A fusion gene that results from a chromosomal translocation t(15;17)(q22;q21) which fuses the first 3 exons of the PML gene with the last 7 exons of the RARA gene. This fusion is associated with acute promyelocytic leukemia. Three transcript variants are possible based on the three breakpoint clusters in the PML gene.

**Synonyms:** - PML-RAR - PML-RAR - PML-RAR Alpha Fusion Gene - PML-RARA Fusion Gene - PML-RARa - PML-RARa Fusion Gene - PML-RARalpha - PML::RARA Fusion Gene