RUNX1/MECOM Fusion Gene

**Semantic type:** Gene or Genome

**Definition:** A fusion gene (~5.9 kb) that results from a chromosomal translocation t(3;21)(q26;q22) which fuses the first 5 exons of the RUNX1 gene to most of the MECOM gene. This rearrangement is associated with acute myelogenous leukemia, chronic myelogenous leukemia and myelodysplasic syndrome.

**Synonyms:** - AME Fusion Gene - AML-EAP Fusion Gene - AML/EAP Fusion Gene - AML/MDS1/EVI1 Fusion Gene - AML1-EVI-1 Fusion Gene - AML1-MDS1-EVI1 Fusion Gene - AML1/MDS1 Fusion Gene - AML1/MDS1/EVI1 Fusion Gene - MDS1/AML1 Fusion Gene - RUNX1-EVI1 Fusion Gene - RUNX1-MECOM Fusion Gene - RUNX1/EVI1 Fusion Gene - RUNX1::MECOM Fusion Gene