Alanosine

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** An amino acid analogue and antibiotic derived from the bacterium Streptomyces alanosinicus with antimetabolite and potential antineoplastic activities. L-alanosine inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate, an intermediate in purine metabolism. L-alanosine-induced disruption of de novo purine biosynthesis is potentiated by methylthioadenosine phosphorylase (MTAP) deficiency. The clinical use of this agent may be limited by its toxicity profile. MTAP is a key enzyme in the adenine and methionine salvage pathways.

**Synonyms:** - 3-(Hydroxynitrosoamino)-L-alanine - ALANOSINE - ALANOSINE - L-2-Amino-3-(hydroxynitrosoamino)propionic Acid - L-2-Amino-3-[(N-nitroso)hydroxylamino]propionic Acid - L-2-Amino-3-[(N-nitroso)hydroxylamino]propionic acid - L-Alanosine - L-Alanosine Sodium - SDX-102 - alanosine