TMPRSS2/ETV1 Fusion Gene

**Semantic type:** Gene or Genome

**Definition:** A fusion gene that results from a chromosomal translocation t(7;21)(p21;q22) which fuses the 5' end of the TMPRSS2 gene with exon 4 of the ETV1 gene. This rearrangement is associated with prostate carcinoma and androgen-dependent expression of this fusion gene results in overexpression of ETS translocation variant 1 protein activity.

**Synonyms:** - ETV1/TMPRSS2 Fusion Gene - TMPRSS2-ETV1 Fusion Gene - TMPRSS2::ETV1 Fusion Gene