Levonordefrin Hydrochloride

**Semantic type:** Pharmacologic Substance

**Definition:** The hydrochloride salt of levonordefrin, a synthetic catecholamine and norepinephrine derivative with sympathomimetic and antihypertensive effects. Levonordefrin's antihypertensive effect is exerted through activation of alpha 2-adrenergic receptors in the cardiovascular control center of the CNS thereby suppressing the sympathetic output from the brain and subsequently lowering blood pressure. Levonordefrin binds to and activates peripheral alpha 2- adrenergic receptors, thereby causing vasoconstriction.

**Synonyms:** - (-)-2-amino-1-(3,4-dihydroxyphenyl)propan-1-ol Hydrochloride - 1,2-benzenediol, 4-((1R,2S)-2-amino-1-hydroxypropyl)-, Hydrochloride (1:1) - Corbadrine Hydrochloride - L-Nordefrin HCl - LEVONORDEFRIN HYDROCHLORIDE