Signaling Lymphocytic Activation Molecule Family

**Definition:** Type-I membrane glycoproteins that are expressed primarily on the surface of CD4 or CD8-positive T-CELLS; NATURAL KILLER CELLS; and some populations of B CELLS. They are characterized by an N-terminal, extracellular IMMUNOGLOBULIN-LIKE DOMAIN and a membrane-proximal IMMUNOGLOBULIN C2-SET DOMAIN. SLAMF receptors typically signal through homophilic interactions and are important for mediating the immune response and immune cell differentiation.

**Tree numbers:** - D09.400.430.890.736 - D12.776.395.550.736 - D12.776.543.550.746 - D12.776.543.750.705.970

**Synonyms:** - Signaling Lymphocytic Activation Molecules - SLAM Family Receptors - SLAMF Receptors - Signaling Lymphocytic Activation Molecule Family Receptors - Signaling Lymphocytic Activation Molecule Receptors