Pyrin Domain

**Definition:** A protein interaction domain of the death domain superfamily. It is characterized by a 6-helix bundle similar to those that occur in DEATH DOMAIN RECEPTORS. Pyrin domains are present in a variety of proteins, especially those that function in INFLAMMASOMES; AUTOPHAGY; and APOPTOSIS. They form homodimers or heterodimers with death domain proteins to facilitate the assembly of signaling complexes.

**Tree numbers:** - G02.111.570.820.709.275.750.500.395.875

**Synonyms:** - PYD Domain - PADD Domain - PAAD-DAPIN-PYRIN Domain - DAPIN Domain