Death Domain Superfamily

**Definition:** A family of structurally-related protein interaction domains characterized by 6-helical closed bundle fold, with Greek key topology and an internal pseudo two-fold symmetry. Death-like domains occur in many proteins that are essential for APOPTOSIS, including CASPASE RECRUITMENT DOMAIN CONTAINING PROTEINS and DEATH DOMAIN RECEPTORS.

**Tree numbers:** - G02.111.570.820.709.275.750.500.395

**Synonyms:** - Death-Like Domains - Death-Like Domain