Suppressor of Cytokine Signaling 3 Protein

**Definition:** A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS3 inhibits cytokine signaling by binding to RECEPTOR PROTEIN-TYROSINE KINASES as well as CYTOKINE RECEPTOR GP130; ERYTHROPOIETIN RECEPTORS; INSULIN RECEPTOR; and the LEPTIN RECEPTOR. Its functions include suppression of ERYTHROPOIESIS in the fetal liver.

**Tree numbers:** - D12.644.360.024.374.750 - D12.776.157.057.249.750 - D12.776.476.024.437.750

**Synonyms:** - SOCS3 Protein - Suppressor of Cytokine Signaling Protein 3