Suppressor of Cytokine Signaling Proteins

**Definition:** A family of structurally related proteins that are induced by CYTOKINES and negatively regulate cytokine-mediated SIGNAL TRANSDUCTION PATHWAYS. SOCS proteins contain a central SH2 DOMAIN and a C-terminal region of homology known as the SOCS box.

**Tree numbers:** - D12.644.360.024.374 - D12.776.157.057.249 - D12.776.476.024.437

**Synonyms:** - SOCS Proteins - Suppressors of Cytokine Signaling Proteins