APOBEC-3G Deaminase

**Definition:** An APOBEC deaminase that functions as an inhibitor of RETROVIRIDAE replication and inhibits the mobility of RETROTRANSPOSONS via deaminase-dependent and independent mechanisms. It is selective for SINGLE-STRANDED DNA and does not deaminate double-stranded DNA or single or DOUBLE-STRANDED RNA. It exhibits potent antiviral activity against VIF PROTEIN deficient HIV-1 through the creation of hypermutations in the VIRAL DNA. It also has anti-viral activity against SIMIAN IMMUNODEFICIENCY VIRUSES and HEPATITIS B VIRUS.

**Tree numbers:** - D08.811.277.151.486.250.500.750 - D12.776.066.032

**Synonyms:** - APOBEC-3G dC-dU Editing Enzyme - CEM15 Protein - APOBEC3G Deaminase - APOBEC-3G Protein - APOBEC3G Protein - APOBEC-Related Cytidine Deaminase - APOBEC-Related Protein