Wnt-5a Protein

**Definition:** A Wnt protein and ligand for FRIZZLED RECEPTORS that may function as an inhibitor or activator of the WNT SIGNALING PATHWAY. For example, it activates signaling in the presence of Frizzled-4 but is inhibitory when coupled with ROR2 TYROSINE KINASE. It is required for axis formation during EMBRYOGENESIS and inhibits the proliferation, migration, and invasiveness of cancer cells.

**Tree numbers:** - D12.776.467.984.050 - D12.776.624.664.700.962 - D23.529.984.050

**Synonyms:** - Wnt5a Protein - Wingless-Type MMTV Integration Site Family, Member 5A