Wnt Proteins

**Definition:** Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN.

**Tree numbers:** - D12.776.467.984 - D23.529.984

**Synonyms:** - Wnt Protein - Wingless Type Proteins - Wingless Type Protein - Wnt Factors - Wnt Factor