Patched-1 Receptor

**Definition:** A patched receptor for several HEDGEHOG PROTEINS that associates with the SMOOTHENED RECEPTOR to modulate hedgehog signaling. It is also a TUMOR SUPPRESSOR PROTEIN; mutations in the patched-1 gene are associated with BASAL CELL NEVUS SYNDROME; SQUAMOUS CELL CARCNIOMA of the ESOPHAGUS; trichoepitheliomas, and CARCINOMA, TRANSITIONAL CELL of the URINARY BLADDER.

**Tree numbers:** - D12.776.543.750.058.500 - D12.776.624.776.633.500

**Synonyms:** - Patched Receptor-1 - PTCH1 Protein - Patched-1 Protein - Patched Homolog-1