P-type ATPases

**Definition:** A highly conserved family of ATPases that facilitate the transport of lipids and cations across the plasma membrane. Structurally, they are elongated ALPHA-HELICES constituting five functionally distinct domains: three cytoplasmic domains A, N, and P which contain the catalytic sites, and two transmembrane domains. The N domain phosphorylates the P-domain at an invariant ASPARTATE residue, which, in turn, is dephosphorylated by the A domain. The phosphorylation and dephosphorylation cycles drive conformational changes in the protein between two states (E1 and E2), which allow the substrate to access the other side of the membrane.

**Tree numbers:** - D08.811.277.040.025.314 - D12.776.157.530.813 - D12.776.543.585.813

**Synonyms:** - P-type ATPase - P-type Adenosine Triphosphatase - Phosphorylation-type Adenosine Triphosphatases - E1-E2 ATPases - P-type Adenosine Triphosphatases - Phosphorylation-type ATPases - E1-E2 ATPase - P Type Atpase