Copper-Transporting ATPases

**Definition:** P-type ATPases which transport copper ions across membranes in prokaryotic and eukaryotic cells. They possess a conserved CYSTEINE-HISTIDINE-SERINE (CPx) amino acid motif within their transmembrane helices that functions in cation translocation and catalytic activation, and an N-terminal copper-binding CxxC motif that regulates enzyme activity. They play essential roles in intracellular copper homeostasis through regulating the uptake, efflux and storage of copper ions, and in cuproprotein biosynthesis.

**Tree numbers:** - D08.811.277.040.025.314.500 - D12.776.157.530.450.250.578.750 - D12.776.157.530.813.500 - D12.776.543.585.450.250.578.750 - D12.776.543.585.813.500

**Synonyms:** - Copper-Transporting ATPase - Copper-Transporting Adenosine Triphosphatases - Cu(+)-Transporting ATPases - Cu-Transporting ATPases