Cytokine TWEAK

**Definition:** A proteolytically-cleaved membrane glycoprotein and member of the TNF superfamily that is highly expressed in a variety of tissues including heart, pancreas, brain, and peripheral blood lymphocytes. The secreted extracellular form is a weak inducer of APOPTOSIS for some cell types and a ligand for the FN14 RECEPTOR. It mediates activation of NF-KAPPA-B and promotes ANGIOGENESIS and proliferation of ENDOTHELIAL CELLS, as well as expression of cytokines involved in INFLAMMATION.

**Tree numbers:** - D12.644.276.374.750.155 - D12.776.467.374.750.155 - D23.529.374.750.155

**Synonyms:** - Tumor Necrosis Factor Ligand Superfamily Member 12 - TNF-Related Weak Inducer of Apoptosis - Apo3 Ligand - TWEAK Cytokine