Aldo-Keto Reductase Family 1 Member C2

**Definition:** Aldo-keto reductase that functions with 5-alpha and 5-beta-steroid reductases to convert steroid hormones into the 3-alpha or 5-alpha and 3-alpha or 5-beta-tetrahydrosteroid, including 5-ALPHA-DIHYDROTESTOSTERONE to ANDROSTANE-3,17-DIOL. It also binds to BILE ACIDS. Mutations in the AKR1C2 gene are associated with Type 8 DISORDER OF SEX DEVELOPMENT, 46,XY (SRXY8).

**Tree numbers:** - D08.811.682.047.150.700.156.750 - D08.811.682.047.820.284.875

**Synonyms:** - Dihydrodiol Dehydrogenase 2 - AKR1C2 Protein - Dihydrodiol Dehydrogenase-Bile Acid Binding Protein