Aldo-Keto Reductases

**Definition:** A family of NADPH-dependent oxidoreductases that reduce carbonyl substrates including sugar-aldehydes, KETOSTEROIDS; keto-prostaglandins, and QUINONES. They are monomers of approximately 37 KDa and are characterized by a parallel beta-8 (BETA SHEET)-alpha 8 (ALPHA HELICES)-barrel structure that contains the NADP binding site. This conformation favors aromatic and apolar substrates.

**Tree numbers:** - D08.811.682.047.150.700.156 - D08.811.682.047.820.284

**Synonyms:** - Aldo-Keto Reductase Family - Aldo-Keto Reductase Superfamily