Nedd4 Ubiquitin Protein Ligases

**Definition:** E3 ubiquitin ligases that consist of four WW DOMAINS. They accept UBIQUITIN from E2 UBIQUITIN-CONJUGATING ENZYME as a thioester via their C-terminal HECT domains and transfer it specifically to the 63rd LYSINE residue (Lys-63) of target proteins. NEDD4 targets include many proteins and receptors with important functions for cell growth and homeostasis such as VEGFR-2; FGFR1 TYROSINE KINASE; and ERBB-4 RECEPTOR. They play a critical role in the internalization of these receptors, their degradation by LYSOSOMES, and also function as part of the ESCRT complex in VIRUS RELEASE.

**Tree numbers:** - D05.500.199.500 - D08.811.464.938.750.257 - D12.776.543.990.493.500

**Synonyms:** - Nedd4 Proteins - Neuronal Precursor Cell-Expressed Developmentally Down-Regulated 4 Ligase