Endosomal Sorting Complexes Required for Transport

**Definition:** A set of protein subcomplexes involved in PROTEIN SORTING of UBIQUITINATED PROTEINS into intraluminal vesicles of MULTIVESICULAR BODIES and in membrane scission during formation of intraluminal vesicles, during the final step of CYTOKINESIS, and during the budding of enveloped viruses. The ESCRT machinery is comprised of the protein products of Class E vacuolar protein sorting genes.

**Tree numbers:** - D05.500.199 - D12.776.543.990.493

**Synonyms:** - Endosomal Sorting Complex Required for Transport - Endosomal Sorting Complex Required for Transport Machinery - ESCRT Complexes - ESCRT Machinery