Angiopoietin-like Proteins

**Definition:** A family of proteins that is structurally similar to ANGIOPOIETINS but do not bind angiopoietin receptors. They are characterized by an amino-terminal coiled-coil domain, a linker region, and a carboxy-terminal FIBRINOGEN-like domain with the exception of ANGPTL8, which lacks the fibrinogen-like domain. They function in a variety of developmental and physiological processes, including INFLAMMATION, lipid metabolism, hematopoietic stem cell activity, and cancer metastasis.

**Tree numbers:** - D12.644.276.100.050 - D12.776.467.100.050 - D23.529.100.050

**Synonyms:** - Angiopoietin-related Protein - Angiopoietin-like Protein