Angiopoietin-Like Protein 4

**Definition:** A secreted angiopoietin-like protein expressed under hypoxic conditions by ENDOTHELIAL CELLS. It inhibits cell proliferation, cell migration, and tubule formation; the inactive form accumulates in the endothelial EXTRACELLULAR MATRIX, reducing vascular leakage. ANGPTL4 has direct roles in regulating glucose and lipid metabolism, as well as INSULIN SENSITIVITY, and may also function as a regulator of angiogenesis and tumorigenesis.

**Tree numbers:** - D12.644.276.100.050.400 - D12.776.467.100.050.400 - D23.529.100.050.400

**Synonyms:** - ANGPTL4 Protein - Angiopoietin-related Protein 4