Tripartite Motif-Containing Protein 28

**Definition:** A tripartite motif protein consisting of an N-terminal RING finger, two B-box type ZINC FINGERS, and C-terminal PHD domain. It functions as a transcriptional repressor by associating with Kruppel-association box domain (KRAB domain) transcription factors and has E3-SUMO-ligase activity towards itself and also sumoylates INTERFERON REGULATORY FACTOR-7 to reduce its activity as a transcriptional activator. It can also function as a ubiquitin protein ligase towards TUMOR SUPPRESSOR PROTEIN P53.

**Tree numbers:** - D08.811.464.938.750.782 - D12.776.260.703.675 - D12.776.930.780.911 - D12.776.934.875

**Synonyms:** - TRIM28 Protein