Mechanistic Target of Rapamycin Complex 1

**Definition:** An evolutionarily conserved multiprotein complex that functions as a cellular energy sensor and regulator of protein synthesis for cell growth and proliferation. It consists of TOR SERINE-THREONINE KINASES; REGULATORY-ASSOCIATED PROTEIN OF MTOR (RAPTOR); MLST8 PROTEIN; and AKT1 substrate 1 protein. The activity of the complex is regulated by SIROLIMUS; INSULIN; GROWTH FACTORS; PHOSPHATIDIC ACIDS; some amino acids or amino acid derivatives, and OXIDATIVE STRESS.

**Tree numbers:** - D05.500.337 - D08.811.913.696.620.682.700.931.500 - D12.776.476.563.931.500

**Synonyms:** - TOR Complex 1 - Target of Rapamycin Complex 1 - mTORC1 Complex - TORC1 - mTORC1