HLA-E Antigens

**Definition:** Class I human histocompatibility (HLA) antigens encoded by genes at the E locus on chromosome 6. They bind a restricted subset of peptides derived from the leader peptides of other class I molecules. They primarily are involved with down-regulating cytolytic activity of NK CELLS and restricting non-canonical CD8-POSITIVE T LYMPHOCYTES.

**Tree numbers:** - D09.400.430.890.489.850 - D12.776.395.550.489.850 - D12.776.543.550.439.850 - D23.050.301.500.100.850 - D23.050.705.552.100.850

**Synonyms:** - HLA E Antigens